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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK8
All Species:
26.97
Human Site:
S271
Identified Species:
45.64
UniProt:
Q86SG6
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86SG6
NP_835464.1
692
74806
S271
N
L
H
T
D
V
G
S
V
R
M
R
R
A
E
Chimpanzee
Pan troglodytes
XP_511801
843
90571
P422
G
G
S
L
S
L
G
P
H
L
S
C
R
A
E
Rhesus Macaque
Macaca mulatta
XP_001106986
781
84378
S360
N
L
H
T
D
V
G
S
V
R
M
R
R
A
E
Dog
Lupus familis
XP_548291
727
78319
S299
N
L
H
T
D
L
G
S
V
R
M
R
R
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q91ZR4
698
75246
S271
N
I
H
T
D
V
G
S
V
R
M
R
R
A
E
Rat
Rattus norvegicus
NP_001099274
698
75236
S271
N
I
H
T
D
V
G
S
V
R
M
R
R
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512532
832
89432
S255
N
L
Y
T
D
V
G
S
V
K
M
R
R
A
K
Chicken
Gallus gallus
XP_415822
728
79098
S271
N
L
Y
T
D
V
G
S
V
K
M
R
R
P
E
Frog
Xenopus laevis
Q7ZZC8
944
104521
D296
I
L
S
W
R
R
R
D
M
E
E
K
V
S
M
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
N271
N
L
Y
T
D
I
G
N
V
K
M
R
R
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_490968
998
111830
L447
S
S
V
S
F
T
T
L
Y
D
L
H
V
P
T
Sea Urchin
Strong. purpuratus
XP_001201534
446
48490
D62
C
D
V
I
K
I
G
D
F
G
I
S
K
I
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
P222
I
N
R
S
I
V
P
P
L
P
A
Q
Y
S
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P48479
858
94329
A326
E
L
D
S
K
L
S
A
L
E
T
E
K
S
S
Conservation
Percent
Protein Identity:
100
75.4
87
88.8
N.A.
93.5
93.4
N.A.
68.7
76.9
24.7
73.8
N.A.
N.A.
N.A.
23.2
38.2
Protein Similarity:
100
76.9
87.8
91
N.A.
96.4
95.4
N.A.
74
85.1
39.5
85.2
N.A.
N.A.
N.A.
37.8
50.8
P-Site Identity:
100
26.6
100
93.3
N.A.
93.3
93.3
N.A.
80
80
6.6
66.6
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
100
93.3
26.6
93.3
N.A.
N.A.
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.2
N.A.
21.7
Protein Similarity:
N.A.
N.A.
N.A.
44
N.A.
37.1
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
8
0
0
50
8
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
8
8
0
58
0
0
15
0
8
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
15
8
8
0
0
58
% E
% Phe:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
8
8
0
0
0
0
72
0
0
8
0
0
0
0
0
% G
% His:
0
0
36
0
0
0
0
0
8
0
0
8
0
0
0
% H
% Ile:
15
15
0
8
8
15
0
0
0
0
8
0
0
15
0
% I
% Lys:
0
0
0
0
15
0
0
0
0
22
0
8
15
0
8
% K
% Leu:
0
58
0
8
0
22
0
8
15
8
8
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
58
0
0
0
8
% M
% Asn:
58
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
15
0
8
0
0
0
15
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
8
0
8
8
8
0
0
36
0
58
65
0
0
% R
% Ser:
8
8
15
22
8
0
8
50
0
0
8
8
0
22
8
% S
% Thr:
0
0
0
58
0
8
8
0
0
0
8
0
0
0
8
% T
% Val:
0
0
15
0
0
50
0
0
58
0
0
0
15
0
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
22
0
0
0
0
0
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _